Santa Cruz Biotechnology Fkbp12 Mouse Monoclonal Western Antibody

Description: A synthetic peptide for use as a blocking control in assays to test for specificity of FKBP12 antibody, catalog no. 70R-11962

Description: Peptidyl-prolyl cis-trans isomerase FKBP1A, a member of the FKBP-type PPIase family and FKBP1 subfamily, is also known as FK506-binding protein 1A, immunophilin FKBP12 and 12 kDa FK506-binding protein, which contains one PPIase FKBP-type domain. FKBP1A is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus).FKBP1A interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. FKBP1A can also interact with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. Furthermore, FKBP1A can recruite SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal.

Description: Human FKBP12 (FK506 binding protein 1A, transcript variant 12A), GenBank Accession No. NM_054014, full length with N-terminal His-tag, MW= 13.1 kDa, expressed in an E. coli expression system. 5References: 1. Knappe,T.A. et al., J. Mol. Biol. 368 (5), 1458-1468 (2007). 2. Wear,M.A. et al., Protein Expr. Purif. 51 (1), 80-95 (2007).

Description: Mouse monoclonal to FKBP12