Aviva Systems Biology Okeh02565

Description: Description of target: One of the most important functions of Noradrenaline is its role as the neurotransmitter released from the sympathetic neurons affecting the heart. An increase in Noradrenaline from the sympathetic nervous system increases the rate of contractions. When Noradrenaline acts as a drug, it increases blood pressure by increasing vascular tone (tension of vascular smooth muscle) through alpha-adrenergic receptor activation; a reflex bradycardia homeostatic baroreflex is overcome by a compensatory reflex preventing an otherwise inevitable drop in heart rate to maintain blood pressure. Noradrenaline is synthesized from dopamine by dopamine beta-hydroxylase.[8] It is released from the adrenal medulla into the blood as a hormone, and is also a neurotransmitter in the central nervous system and sympathetic nervous system, where it is released from noradrenergic neurons in the locus coeruleus. The actions of norepinephrine are carried out via the binding to adrenergic receptors.;Species reactivity: All;Application: ;Assay info: Assay Methodology: Quantitative Competitive ELISA;Sensitivity: 9.8 pg/mL