Lc Laboratory Bim

Description: Bim is a protein encoded by the BCL2L11 gene which is approximately 22,1 kDa. Bim is localised to the mitochondrion. It is involved in the activation of BH3-only proteins, apoptosis modulation and signalling, p75 NTR receptor-mediated signalling and MAPK signalling. It forms a hetero- or homodimers and acts as anti- or pro-apoptotic regulator that is involved in a wide variety of cellular activities. Bim isoform gamma is most abundantly expressed in small intestine and colon. Other isoforms are widely expressed with tissue-specific variation. Mutations in the BCL2L11 gene may result in ocular hyperemia and autoimmune lymphoproliferative syndrome. STJ91855 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Bim.

Description: Purified Polyclonal BIM antibody

Description: Rabbit polyclonal BIM antibody

Description: BIM Peptide

Description: Bim Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat. Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.